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Glioblastoma (GBM). GBM is the most Pittsburgh Pirates MLB Hawaiian Shirt Sea Shores The Sport Of Two Halves Shirts and most aggressive brain cancer. Itβs highly invasive, which makes complete surgical removal impossible. And because of the blood-brain barrier (BBB), it doesnβt respond to any chemotherapy. The standard-of-care entails multiple rounds of surgery and radiotherapy, yet the five year survival is lower than 5%. Pancreatic cancer (PDAC). PDAC is a notoriously stubborn cancer. The only effective treatment is a very painful and very complex operation called βthe Whipple procedureβ. However, only 20% of patients are eligible for such operation. And even for those lucky patients, only 20% survived more than five years. For the rest majority of patients, the chance of survival is negligible, because PDAC hardly responds to any form of chemotherapy or radiotherapy. The five year survival overall is 6%.
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Who was the worst coach in NFL history? When discussing the worst coaches in NFL history, assuming youβre only referring to head coaching duties, names like Rod Marinelli, Dave Shula, Lou Holtz, and Lane Kiffin are often bandied about, amongst others. These characters represent two major categories of Pittsburgh Pirates MLB Hawaiian Shirt Sea Shores The Sport Of Two Halves ShirtsΒ professional coaching careers; the highly-regarded NFL assistant who couldnβt hack it as a head coach (Gus Bradley, Kevin Gilbride, etc.), and the successful college coach who was unable to transition into coaching multimillionaires (Spurrier, Saban, et al.). In defense of the first four coaches mentioned above, all of them inherited horrible teams. But a few coaches have taken on decently successful franchises, yet completely failed during their fleeting NFL careers.
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