The likelihood of people taking these vaccines in the BILLIONS is so high that everyone in the I just took a dna test turns out im 100 that bookworm shirt basically took it as a golden opportunity for printing money. No wonder there’s so many. Pfizer-biontech, moderna and astrazeneca seems to be taking most of the cake tho. There’ll be loooooots more for the other players no worries, especially for what should be lifetime vaccines which I heard were underway? Not sure if that’s true so take it with a pinch of salt.I think the J&J will become the most popular in the long run. No need for high refrigeration and only being 1 shot is a godsend in terms of logistical deployment, esp. to places that don’t have the infrastructure to reliably dole out the more sensitive vaccines.From safest and most effective looks like mRNA are the king, but as pointed out storage is the issue.I don’t know though whether J&J is. To me that whole 1 shot thing is a “marketing gimmick” 🙂 It’s very similar to other vector vaccines, like AZ. The issue with them is that they need another virus (adenovirus) to deliver the DNA of the spike protein. Because of that, your body not only will produce antibodies for the spike protein, but also for the adenovirus used. That makes things problematic for the second shot, because your immune system will start fighting it before the vaccine does anything.Russia’s Sputnik V solved it by using a different adenovirus for the 2nd shot, while J&J went “let’s turn this disadvantage into an advantage; vaccine has lesser efficacy, but you’ll only take a single shot”Down the line I wouldn’t be surprised if AZ will get approved as a single shot only.AZ could be more welcome in the rest of the world since unlike others, university of Oxford did not seek profit and the cost of AZ vaccine is just cost of the production.They actually were trying to make the vaccine public domain so anyone could produce it, but ironically it was Gates that stopped them from doing that.That seems evil at first, but his argument was that if they make it public domain and companies will start producing it without proper care and people start to die, not only will it affect trust in Oxford vaccine but also in other vaccines.
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The fact that there are so many efforts in parallel us why it doesn’t make a I just took a dna test turns out im 100 that bookworm shirt sense to ‘wait for the 2.0’ like some people imagine. We are effectively on what would have been the seventh or eighth generation vaccine if the work had all been serialized at one company or university. We would have started with the most mature technology, rolled it out, then tested another option. That would have been disappointing, so we would try a third technique, etc. Since everybody was working at once, some companies were starting out by working on technology that would have been low on the list of things to try.Honestly, I was super skeptical that the mRNA technology would work as well as they hyped it. But the proof was in the pudding, and they proved it worked really well and made it at industrial scale before the older protein vaccine tech could do the same. If we had to pick just one project to fund in early 2020, we might not have a good vaccine yet, and the mRNA vaccines might still be years away waiting for R and D funding.